Hydroxyzine Pamoate is in a class of medicines called antihistamines. It has weak sedative, anticholinergic, and antiemetic properties. It leads to sedation by inhibiting the hypothalamic H-1 histamine receptors involved in the sleep-wake cycle in humans.
The drug sells under the brand names Atarax and Vistaril.
Cetirizine is an over-the-counter antihistamine used to treat allergic rhinitis, dermatitis, and urticaria. It is non-sedating for most people.
Hydroxyzine blocks the action of histamine. This is a substance in the body that leads to allergic symptoms. It also decreases activity in the central nervous system (CNS).
Adults and children take Hydroxyzine Pamoate to relieve itching resulting from allergic reactions on the skin, such as hives. It is also used alone or in combination with other medicines to treat medical conditions like anxiety and tension in adults and children.
The medication is also used along with other medicines in adults and children for sedation before and after general anesthesia for surgery.
The drug is available in the following forms:
Usually, Hydroxyzine is taken three or four times a day. Follow the directions on the prescription label correctly. Ask your doctor or a healthcare professional to explain any parts of the treatment you do not understand.
Do not consume more or less Hydroxyzine or take it more often than prescribed by your doctor. If you take Hydroxyzine by suspension, shake it well before use to mix the solution evenly.
Antihistamines like Hydroxyzine are safe when taken correctly. Here are some tips and advice to avoid consuming too much of the drug:
Taking Hydroxyzine may result in side effects and risks. Speak with your doctor or a healthcare professional if any of the following symptoms are severe or persist after ingestion:
Some side effects can be more serious. If you experience any of these symptoms or side effects, speak with your doctor or a healthcare professional immediately:
If you experience any of the following side effects or symptoms of a severe skin condition, stop taking Hydroxyzine and speak with your doctor or healthcare professional immediately:
Hydroxyzine may lead to other side effects. Speak with your doctor if you notice any abnormalities while taking this medicine. If you have glaucoma, you should also speak with your doctor before taking the drug.
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Yes, it is possible to overdose on Hydroxyzine. Hydroxyzine overdose occurs when an individual takes more than the usual or recommended amount of the medication. This can be by accident or intentionally.
Allergy medications like Hydroxyzine are considered safe when used correctly and can deliver quick relief from symptoms. However, an antihistamine overdose can be life-threatening, so it is essential to understand proper dosing to avoid toxicity.
Hydroxyzine can interact with other drugs you take. If you do not know whether it is safe to take Hydroxyzine with another medicine, speak with your doctor or a pharmacist.
Drug interactions may alter how your medications work or increase your risk for severe side effects. A good idea is to keep a list of all the products you use and share it with your doctor or pharmacist. This includes prescription and non-prescription drugs and herbal supplements.
Do not begin, stop, or alter the dosage of any medicines without a healthcare professional’s approval.
The following drugs may cause drowsiness, and you should tell your doctor or pharmacist if you are planning on taking them with Hydroxyzine:
Always check the disclaimer labels on your medications, especially allergy or cough-and-cold products. This is because they may contain ingredients that lead to drowsiness.
Do not use Hydroxyzine with any other antihistamines applied to the skin, like diphenhydramine cream, ointment, or spray. This is because increased side effects could occur.
Dilated pupils are the most common symptom of a Hydroxyzine overdose. Below is the full list of the vital signs of a Hydroxyzine overdose:
It is challenging to predict when an overdose may occur or how long it will last. The length of overdose symptoms depends on various factors, such as how much Hydroxyzine was taken and the body weight and size of the individual.
If you are concerned about a potential overdose, it is essential to seek medical attention immediately. Symptoms do not go away on their own. Without proper medical help, overdoses are almost always fatal.
Recovery from a Hydroxyzine overdose is likely if the person survives the first 24 hours. However, the following complications may lead to permanent disability:
Few people die from an antihistamine overdose unless they have severe heart rhythm disturbances or breathing issues. However, there have been some deaths due to antihistamine toxicity. These include both accidental and intentional overdoses.
Deaths typically occur when a Hydroxyzine overdose leads to severe complications, including:
Each individual’s tolerance to antihistamines varies. However, toxicity typically occurs when a person consumes three to five times the recommended dosage.
Some side effects and symptoms of taking antihistamines can mimic overdosage of the drug. These side effects include:
These side effects do not usually require medical attention. They may subside as your body adjusts to the medicine.
However, it is always best to check with a doctor if you have side effects. You may need to adjust your dosage or take a different medicine.
The difference between side effects and an overdose is usually the severity of symptoms. If someone is experiencing the following symptoms, they must visit the emergency room:
Before calling for emergency help, have the following information ready:
Antihistamine overdose treatment works to stabilize the individual’s health and provides supportive care. The patient will likely receive activated charcoal in the hospital. This product is typically used in emergencies to help reverse the effects of drug poisoning.
Activated charcoal works as an antidote, stopping the absorption of toxins and chemicals from entering the body from the stomach. Toxins then bind to the charcoal and leave the body through bowel movements.
Additionally, treatment may include cardiac and respiratory monitoring. The prognosis depends on the quantities of antihistamine consumed and the extent of an overdose. However, a full recovery is possible with immediate treatment.
If possible, bring the antihistamine product to the hospital with you.
Tests that may be performed during an antihistamine overdose include:
Treatments may include:
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Hydroxyzine, MedlinePlus, January 2021, https://medlineplus.gov/druginfo/meds/a682866.html
Hydroxyzine overdose, MedlinePlus, February 2021, https://medlineplus.gov/ency/article/002654.htm
Borowy CS, Mukherji P. Antihistamine Toxicity. [Updated 2020 Nov 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan, https://www.ncbi.nlm.nih.gov/books/NBK482318/
FDA warns about serious problems with high doses of the allergy medicine diphenhydramine (Benadryl), United States Food and Drug Administration, September 2020, https://www.fda.gov/drugs/drug-safety-and-availability/fda-warns-about-serious-problems-high-doses-allergy-medicine-diphenhydramine-benadryl
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