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Updated on November 16, 2022
5 min read

Can You Drink Alcohol While Taking Prednisone?

Key Takeaways

  • Prednisone is a corticosteroid tablet that has anti-inflammatory effects, can suppress the immune system, and can be used to replace deficient cortisol levels. 
  • Mixing alcohol and prednisone can cause indigestion, a weakened immune system, mood changes, high blood sugar, and high blood pressure.
  • It's best to abstain from drinking alcohol while on prednisone treatment to prevent different side effects.

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Can you Drink Alcohol with Prednisone?

The FDA does not warn against drinking while on prednisone. And for many, drinking alcohol in moderation while taking prednisolone could be considered safe.

However, drinking while on prednisone may carry heightened risks for some based on prednisone’s effect on lowering the immune system and the side effects of alcohol use. Abstaining from drinking alcohol while on prednisone treatment is always the best option.

Drinking alcohol while on prednisone is not recommended for patients with existing medical conditions. Patients should always consult their doctor before drinking alcohol with prednisone to avoid possible complications.

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Side Effects of Mixing Prednisone and Alcohol

Short-term side effects may include:

  • Indigestion and stomach upset
  • Weakened immune system and greater susceptibility to illness
  • Mood changes and anxiety
  • High blood sugar
  • High blood pressure

Long-term side effects:

  • Depression
  • Ulcerative colitis and peptic ulcers
  • Gastrointestinal bleeding
  • Brittle bone disorders, bone fractures, and osteoporosis
  • Greater risk for type 2 diabetes
  • Slower healing
  • Weight gain

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Dangers of Mixing Prednisone and Alcohol

Long-term use of prednisone and alcohol is linked to an increased risk of certain health problems.

The dangers of mixing prednisone and alcohol include:

  • Suppressed immune system and increased risk of infection
  • A decrease in bone density and risk of developing bone disorders, including osteoporosis, idiopathic osteonecrosis of the femoral head, and fractures
  • Increased blood sugar levels and risk of developing type 2 diabetes and diabetes complications
  • Stomach lining irritation and risk of developing gastrointestinal disorders, including ulcerative colitis, stomach ulcers, gastrointestinal bleeding, and heartburn
  • Mood changes and increased risk of developing depression and anxiety
  • Increased risk of developing a decreased quality of self-care and difficulty managing chronic illness

Patients with pre-existing conditions carry greater risks of developing complications than others. Patients should always speak with their healthcare provider first to avoid complications and learn if drinking while on prednisone is safe for them.

When Can I Start Drinking After Taking Prednisone?

It's best to wait until you're done with prednisone treatment before drinking alcohol again. Wait for around 24 hours after your last prednisone dose, and then slowly start consuming alcohol again. 

This helps ensure you don't experience any adverse effects from mixing alcohol with your medication. You can also talk to your doctor about how much alcohol is safe for you to drink while on prednisone.

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What Else Should You Not Take With Prednisone?

Over 484 drugs are known to interact with prednisone (Drug Interactions).

Common drugs that interact with prednisone include:

  • Antibiotics
  • Antifungals
  • Birth control pills and other hormones
  • Blood pressure medications & blood thinners
  • Diuretics or "water pills"
  • Hepatitis C medications
  • HIV or AIDS medicines
  • Immunosuppressive drugs like cyclosporine
  • Insulin or diabetes medications
  • NSAIDs, including aspirin and ibuprofen 
  • Seizure medications
  • St. John's wort
  • Tuberculosis medications 

Patients taking steroid tablets should also avoid vaccines because steroids suppress the immune system and make them more susceptible to viruses and illnesses.

Patients who need to receive the weakened type of vaccine may do so with the supervision of a health professional. Check with your doctor about what medications you may receive.

Before taking prednisone, patients should tell their healthcare provider what other medications, vitamins, herbal products, and nutritional supplements they take or plan to take to ensure that prednisone is safe for them.

What is Prednisone?

Prednisone is an FDA-approved, delayed-release corticosteroid tablet. This medication has anti-inflammatory effects, can suppress the immune system, and can be used to replace deficient cortisol levels. 

Cortisol is a hormone that is naturally produced in the body and helps to maintain the body’s normal functioning. Prednisone is also used to treat other conditions in patients with normal cortisol levels. It suppresses the immune system and reduces swelling, redness, and allergic reactions.

Prednisone is used to treat a broad range of illnesses, including:

  • Rheumatoid arthritis
  • Immune-mediated blood disorders
  • Certain types of cancer
  • Conditions of the lungs, skin, eyes, kidneys, blood, and thyroid
  • Eye conditions
  • Inflammatory bowel conditions
  • Some endocrine disorders
  • Lupus
  • Multiple sclerosis
  • Respiratory illnesses
  • Skin conditions
  • Severe allergic reactions

What Are The Side Effects Of Short-Term Prednisone Use?

Most patients do not develop side effects if taking steroid tablets for short periods. Side effects may occur with long-term use and/or the sudden withdrawal of the medication after one week of continued intake.

Common side effects of prednisone include: 

  • Adrenal suppression
  • Acne
  • Cataracts
  • Changes in fat distribution
  • Changes in mood and personality
  • Decreased libido
  • Delayed wound healing
  • Dizziness
  • Edema
  • Eye bulging
  • Fatigue
  • Headache
  • Heartburn
  • Increased hair growth
  • Increased sweating
  • Irregular or absent menstrual periods
  • Red or purple blotches or lines under the skin
  • Sleeping disorders
  • Thin, fragile skin
  • Weak muscles

Most side effects subside once treatment stops. Prescribers typically taper the drug into smaller dosages before its discontinuation to decrease its bothersome side effects. Patients should discuss with their doctor if they persist or bother them. 

Prednisone and Alcohol FAQs

Does alcohol kill prednisone?

There is no evidence that alcohol kills prednisone or renders it ineffective. But alcohol abuse and addiction can cause a patient to ignore important self-care habits, which is crucial to patients who use prednisone to treat chronic illnesses.

The effects of alcohol abuse and addiction make it difficult for patients to maintain their medication regimens, which may cause complications. In addition, alcohol can enhance prednisone’s immunosuppressive effects, which may make the patient susceptible to additional illnesses.

What does prednisone do to your body?

Prednisone suppresses the body’s immune system and has anti-inflammatory effects. Prednisone can help lower certain immune-related symptoms, such as inflammation and swelling, by preventing the release of substances in the body that cause inflammation. 

Should I drink more water while taking prednisone?

Drinking too much water can cause excessive fluid retention. This can lead to water intoxication. The usual 8-10 glasses of water allowance per day is still applicable while on prednisone.

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Updated on November 16, 2022
11 sources cited
Updated on November 16, 2022
  1. “Ask the Experts: Contraindications and Precautions”. Immunization Action Coalition, 2020.
  2. Fukushima, W., et al. “The effect of alcohol intake and the use of oral corticosteroids on the risk of idiopathic osteonecrosis of the femoral head: a case-control study in Japan.” The bone & joint journal, 2013. 
  3. “Prednisone.” MedlinePlus, U.S. National Library of Medicine, 2020.
  4. “Prednisone.” National Cancer Institute, National Institutes of Health, 2010.
  5. "Prednisolone tablets and liquid." United Kingdom National Health Service, 2019.
  6. “Prednisone Drug Interactions.”
  7. Puckett, Y., Gabbar, A., and Bokhari, A.A. "Prednisone."  StatPearls Publishing, 2020.
  8. Sampson, H.W.  “Alcohol and Other Factors Affecting Osteoporosis Risk in Women.” National Institute on Alcohol Abuse and Alcoholism, U.S. Department of Health and Human Services, 2003.
  9. “Steroids.” MedlinePlus, U.S. National Library of Medicine, 2020.
  10. “Steroid Tablets.” NHS Choices, 2020.
  11. Tamez-Pérez, H. E., et al. “Steroid hyperglycemia: Prevalence, early detection and therapeutic recommendations: A narrative review.” World journal of diabetes, 2015.

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