Updated on November 7, 2023
4 min read

Is It Safe to Drink Alcohol While Taking Azithromycin?

Can You Drink Alcohol With Azithromycin?

Azithromycin is generally a safe drug on its own. There are no serious dangers associated with drinking alcohol while taking this medication. 

However, if you drink alcohol while taking azithromycin, it could intensify side effects already experienced from taking this medicine. Keep in mind that a typical course of treatment with azithromycin is not very long. It is best to avoid using alcohol while taking this medication.

Drinking any alcohol while fighting an infection is not advised. Alcohol can lead to dehydration, poor sleep, and may ultimately hinder the body’s natural body to heal itself.

What is Azithromycin?

Azithromycin is an FDA-approved macrolide antibiotic medication. It is used to treat many different types of bacterial infections.

It is one of the most common antibiotics prescribed by doctors and can be used to treat several conditions, including:

  • Ear infections
  • Strep throat
  • Pneumonia 
  • Traveler’s diarrhea
  • Bronchitis
  • Sinus infections
  • Chlamydia
  • Tonsillitis
  • Genital ulcer disease
  • Legionnaires’ disease
  • Whooping cough

Azithromycin is typically a short-term antibiotic, but it can also be used longer-term as a preventative treatment.

It can be used to improve chest symptoms and chronic obstructive pulmonary disease (COPD) exacerbations (lung attacks). It is a prescription-only drug and is available in tablet, oral liquid, or injection form. However, injections are typically only administered in the hospital. 

Azithromycin 1

This medicine is usually taken once a day, at the same time each day. You may take azithromycin with or without food. If you develop an upset stomach, taking your dose with food may help.

Most infections should clear within a few days of beginning treatment with azithromycin. However, the full course of medicine should still be taken to prevent any recurring infections or drug resistance.

Azithromycin is sold under the brand name Zithromax, and it is chemically similar to both erythromycin and clarithromycin.


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Side Effects of Azithromycin

Possible side effects of azithromycin include:

  • Upset stomach 
  • Nausea
  • Diarrhea or loose stools 
  • Vomiting
  • Stomach/abdominal pain

In rare cases, serious side effects can occur, such as: 

  • Serious and sometimes life-threatening allergic or skin reactions 
  • Irregular heart rhythm (irregular heartbeat)
  • Liver damage
  • Muscle weakness
  • Eye problems 
  • Loss of consciousness
  • Hearing loss or changes
  • A potentially life-threatening form of diarrhea called C. diff (Clostridium difficile-associated diarrhea)

Contact a healthcare professional if you experience any severe adverse effects after taking this medication.

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Side Effects of Azithromycin and Alcohol

Side effects from taking azithromycin and drinking alcohol are typically the same as those experienced by taking either substance alone. Azithromycin can cause nausea, vomiting, and diarrhea. Similarly, alcohol can cause these symptoms as well as irritate the stomach lining. This increases the production of stomach acid as more alcohol is consumed. 

These effects, combined with the gastrointestinal effects commonly associated with azithromycin, can significantly increase the risk of an upset stomach, vomiting, and diarrhea.

Risks of Mixing Azithromycin and Alcohol

While there are typically no severe side effects from mixing alcohol and azithromycin, there are still risks involved with combining these substances. Both substances can cause diarrhea, and the resulting water loss and electrolyte imbalance in the body can be harmful to your health.  

Additionally, both substances can cause vomiting, leading to a tricky situation if a person vomits soon after taking the medication. If this happens, you should call a doctor to assess whether this would count as a missed dose, and you would need to take another one. 

There are other risks as well, including: 

  • Not allowing your body to properly heal by subjecting it to the effects of alcohol
  • Missing doses due to becoming intoxicated and forgetting, and potentially failing to finish the full course of treatment
  • Making the treatment less effective (even though alcohol does not directly hinder azithromycin from working, it can reduce the body’s natural immune system response and slow down recovery time)

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How Long Does Azithromycin Stay in Your System?

Azithromycin generally stays in your system for a little longer than two weeks (15.5 days, on average) after your final dose. This antibiotic has a reasonably long elimination half-life of 68 hours. This is thought to be prolonged due to the extensive uptake and subsequent slow release of azithromycin stored in tissues within the body. 

Given the relatively harmless interaction with alcohol, there is not an elevated risk of side effects if you choose to drink alcohol before this two-week period ends.

Is Azithromycin Addictive?

Despite the fact that it is only available with a doctor’s prescription, azithromycin is not addictive.  It has no narcotic effects and does not affect your ability to drive a vehicle, operate machinery, or do anything else that requires alertness.

The potential to abuse azithromycin is negligible. 


Mixing NyQuil and alcohol is dangerous and can have serious consequences. It increases the chance of an overdose, liver damage, impaired immune system, and addiction.

Moreover, you shouldn't use NyQuil as a sleep aid or for long-term treatment of symptoms. If you take more than the recommended dose, you may experience withdrawal symptoms.

Talking to your doctor before taking NyQuil and other medications is best. They can help you understand the possible risks and decide if it's a safe choice for you.

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Updated on November 7, 2023

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