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Updated on December 14, 2022
6 min read

How Does Alcohol Affect The Brain?

How Does Alcohol Impact Your Mental Health?

Heavy alcohol use negatively impacts reasoning and overall brain function. It can lead to depression, anxiety, mood disorders, and self-harm (e.g., suicide and cutting).

Regularly drinking four or more alcoholic drinks per day also increases a person’s risk of brain shrinkage almost six times compared to nondrinkers.10

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Alcohol and Your Brain

The following factors determine to what extent alcohol negatively impacts the brain:

  • How often and how much alcohol one drinks
  • When you started drinking alcohol
  • Your general healthcare status
  • Gender
  • Genetics
  • Family history
  • Education level
  • Age
  • If you are at risk of prenatal alcohol exposure

Alcohol and Brain Chemistry

Alcohol abuse changes your brain’s chemistry. It does this by flooding it with endorphins and dopamine, two of the brain's "reward" chemicals.

The reward and pleasure centers of the brain are overloaded, leading to cravings when the alcohol wears off.

With enough repeated exposure to alcohol, the brain becomes dependent on it to produce these chemicals. This can lead to mood disorders.

Between 20 to 67 percent of cases of drug or alcohol abuse are tied to bipolar disorder and depression.7

Therefore, consistent alcohol consumption can lead to both short- and long-term psychological issues.

How Does Alcohol Affect the Brain in the Short-Term?

When a person drinks alcohol regularly, it can adversely affect the brain, especially in the prefrontal cerebral cortex and cerebellum.

The prefrontal cortex is associated with executive functions such as planning and decision-making. The cerebellum is connected to balance and motor function.

When these parts of the brain are affected, it can lead to various side effects and problems, including:

  • Memory problems
  • Poor reflexes and coordination
  • Reduced cognitive performance
  • Vision difficulties
  • Trouble focusing
  • Lack of confidence
  • Mood swings
  • Reduced stress
  • Multitasking
  • Alertness
  • Speech
  • Normal thoughts
  • Blackouts

Alcohol can also cause the hippocampus to shrink if consumed habitually over a long period, even in small amounts. The hippocampus is the area of the brain responsible for memory and learning.

The reasons for this brain shrinkage are unclear.

Research from the Boston University School of Public Health shows that alcohol consumption causes dehydration. Consistent dehydration can have adverse effects on sensitive tissue.

Other studies suggest that the brains of alcoholics are lighter than those who do not have a drinking problem.5 Some of the damage can be reversed if the person decides to stop drinking.

How Does Alcohol Affect the Brain in the Long-Term?

Studies indicate a link between excessive alcohol consumption and complex long-term brain issues.

Heavy drinking while pregnant can also lead to fetal alcohol syndrome (FAS).

Children born with FAS have a range of abnormalities, particularly related to intelligence. The mean IQ of someone with FAS is 79 - significantly lower than the average IQ of 100.8

Serious psychological long-term effects of alcohol use include:

  • Higher chance of developing depression or an anxiety disorder
  • Higher risk of committing suicide
  • Increased alcohol tolerance—this results in heavier drinking to achieve the same effect
  • Increased risk of developing alcohol use disorder (AUD)
  • Irregular brain development
  • Permanent changes to brain chemistry
  • Permanent memory loss
  • Reduced learning ability

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Common Memory Disorders Associated With Alcohol

Alcohol consumption limits the brain’s ability to transfer information from short-term to long-term memory. This is because heavy alcohol use changes your neurons, which results in smaller brain cells.

Over time, and with continued alcohol use, it becomes more difficult to remember previous experiences and simple daily tasks.

Additionally, long-term alcohol use is linked to many serious memory disorders.

A few common disorders include:

Widespread Brain Atrophy

As mentioned above, alcohol use shrinks the brain and decreases the size of brain cells. Heavy drinkers appear to have smaller brains than moderate and non-drinkers.

Symptoms of brain atrophy include:

  • Changes in mood, personality, or behavior
  • Confusion
  • Memory loss
  • Difficulties with judgment or abstract thinking
  • Challenges with learning and thinking

Wernicke-Korsakoff Syndrome

Some researchers believe Wernicke and Korsakoff syndromes are separate yet related disorders. Others believe them to be different stages of the same disorder or disease spectrum.

Wernicke syndrome is considered the acute phase with a shorter duration and more serious symptoms.

Korsakoff syndrome is considered the chronic phase and is a long-lasting condition.

Both of these conditions develop suddenly due to thiamine deficiency. In many cases, those with AUD are deficient in vitamin B1. So, they have a higher risk of developing these disorders.

Wernicke syndrome is characterized by disorientation, loss of coordination (ataxia), and eye abnormalities. Affected people may not display all three symptoms.

Other signs of Wernicke’s include:

  • Sudden disorientation and trouble balancing
  • Excessive weight loss and malnutrition
  • Muscle paralysis in the eyes

Korsakoff Syndrome

If Wernicke’s syndrome is left untreated, Korsakoff syndrome will likely develop. Korsakoff psychosis forms due to permanent damage in critical small areas deep within the brain.

Korsakoff syndrome is characterized by memory impairment, specifically short-term memory loss (i.e., the inability to form new memories).

In some cases, affected people may also have random loss of long-term memories, or even experience false memories (confabulation).

Alcoholic Dementia

Similar to Korsakoff syndrome, alcoholic dementia is a form of alcohol-related brain damage that results in memory loss.

Symptoms of Korsakoff syndrome are typically more severe than those of alcoholic dementia.

The symptoms include:

  • Memory loss
  • Personality changes
  • Impaired executive functioning (planning, organizing, and abstract thinking)
  • Visuospatial problems (ex: inability to copy a clock)
  • Difficulty following simple instructions (ex: cooking recipes)
  • Physical unsteadiness or lack of coordination  
  • Slowed reflexes
  • Inability to recognize sounds, tastes, and smells
  • Confusion
  • Loss of speech

Mental Health Disorders and Alcohol

Long-term alcohol abuse directly impacts brain function and alters your brain chemistry (neurotransmitters). It also affects your body's hormonal systems.

Due to alcohol’s depressive effect, heavy use raises the risk for suicide and self-harm.

Common mental health disorders associated with heavy alcohol use include:


Depression, a group of conditions that lower a person’s mood, affects about 80 percent of alcoholics at some point.

Depression comes in many forms, including clinical depression and bipolar disorder, as well as others. The effects of alcohol can come in waves throughout life.

Since alcohol is a depressant, the substance enhances the symptoms of depression due to its sedative effects.

Anxiety Disorders

Alcohol-induced anxiety is separate from an independent anxiety disorder, but they are often hard to differentiate.

The symptoms of alcohol-induced anxiety usually appear during alcohol withdrawal. They also tend to resolve quickly with treatment and continued abstinence.

Certain anxiety disorders, including social phobia, PTSD, and panic disorder, have an increased co-occurrence with alcohol dependence. Many people abuse alcohol to suppress the symptoms of their anxiety disorder temporarily.

What many people don't know is that alcohol abuse makes anxiety worse. Alcohol use also has high rates of producing panic attacks, which can turn into panic disorder.

Self-Harm and Suicide

Many people drink alcohol to self-medicate. However, alcohol is a depressant. It is linked to many mental health disorders, such as depression.

As a result, the risk of self-harm is high among alcoholics. This may include self-inflicted injuries such as cutting or suicide.

If you or a loved one is self-harming or considering suicide, it is essential to seek medical advice as soon as possible.

People with AUD are 60 to 120 times more likely to participate in self-harm and commit suicide than those free from psychiatric illness.11

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Updated on December 14, 2022
11 sources cited
Updated on December 14, 2022
  1. Alcohol's Damaging Effects on the Brain.” National Institute on Alcohol Abuse and Alcoholism, U.S. Department of Health and Human Services, 2004.
  2. Korsakoff's Syndrome.” Alzheimer's Society.
  3. Merz, Beverly. “This Is Your Brain on Alcohol.” Harvard Health Blog, 13 July 2017.
  4. Ramesh S., M.D., et al. "Alcoholism and Psychiatric Disorders." Alcohol Research & Health. 2002;26: 90-98.
  5. Ritchie, Craig, and Abel Koshy. “Faculty of 1000 Evaluation for Moderate Alcohol Consumption as Risk Factor for Adverse Brain Outcomes and Cognitive Decline: Longitudinal Cohort Study.” F1000 - Post-Publication Peer Review of the Biomedical Literature, 2018.
  6. Symptoms of Alcoholic Dementia.” Alzheimer's Society.
  7. Quello, Susan B., et al. “Mood Disorders and Substance Use Disorder: A Complex Comorbidity.Science & practice perspectives, vol. 3, no. 1, 2005, pp. 13-21.
  8. Rogne, Adrian F., et al. “Intelligence, alcohol consumption, and adverse consequences. A study of young Norwegian men.” Scandinavian journal of public health, vol. 49, no. 4, 2021, pp. 411-418.
  9. Crews, Fulton. “Alcohol-Related Neurodegeneration and Recovery.” Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism, vol. 31, no. 4, 2008, pp. 377-88.
  10. Topiwala, Anya, et al. “Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study.” The British Medical Journal, vol. 357, 2017, p. 2353.
  11. Pompili, Maurizio et al. “Suicidal behavior and alcohol abuse.” International journal of environmental research and public health vol. 7,4 : 1392-431.

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