Which Benzodiazepine Is Most Likely To Cause Dependence?


Key Takeaways
When it comes to managing anxiety, understanding the medications available is key to finding the right fit for your journey towards well-being.
Buspirone and Xanax (alprazolam) are both prescribed for anxiety disorders, yet they operate in distinct ways with their own set of benefits and considerations.
In this article, we’ll talk about the differences between buspirone and Xanax and how they affect the body. We’ll also go over tips for choosing the right medication.
How Do Buspirone and Xanax Work?
The brain has numerous communication channels, one of which relies on a chemical messenger called serotonin. Serotonin is known for regulating mood and anxiety levels.
Buspirone encourages this channel to release more serotonin and promote a sense of calmness. Xanax, on the other hand, enhances the effects of GABA, a neurotransmitter known for its "braking" effect on the brain. It temporarily slows down brain activity and brings about a feeling of calm.
Which Medication is More Effective?
In terms of effectiveness, both medications can alleviate anxiety, but their timelines differ significantly. Buspirone is slow-acting, taking a few weeks to reach its full effect. It's ideal for managing persistent, everyday anxiety, providing a consistent level of calm over time.
Xanax is more quick-acting, making it a valuable tool for managing sudden panic attacks or acute anxiety. However, its effects don't last as long, making it less suitable for managing ongoing anxiety.
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Likelihood of Dependency for Buspirone vs. Xanax
Buspirone is a non-addictive option with a milder side effect profile. Some people initially experience dizziness or nausea.
Xanax, on the other hand, carries a higher risk of dependence and withdrawal. It can also cause drowsiness and impaired coordination.
With prolonged use, your brain can become accustomed to its presence, leading to both physical and psychological dependence. If you’re taking Xanax and have concerns about dependency or withdrawal, we strongly encourage speaking to your healthcare provider.
Can You Use Buspirone or Xanax Long-Term?
When considering long-term anxiety management, it's crucial to weigh the potential benefits against their potential risks, particularly concerning dependency and withdrawal.
If you suddenly stop taking Xanax after prolonged use, you might experience withdrawal symptoms like rebound anxiety, insomnia, or even seizures.
On the other hand, buspirone encourages the release of calming chemicals without the risk of physical dependence. This makes it a potentially safer choice for long-term use, especially if you're concerned about the potential of addiction.
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How to Choose Between Buspirone and Xanax
When choosing between buspirone and Xanax, consider your needs and discuss any concerns with your healthcare provider. If you're looking for a long-term solution with a lower risk of dependency, buspirone might be a good fit.
If you need fast-acting relief for specific situations, Xanax might be helpful, but it's essential to use it under close medical supervision.
Choosing the right medication is a personal decision that should be made in close collaboration with your healthcare provider. Your doctor can assess your unique needs, medical history, and potential interactions with other medications to help you choose the safest and most effective medication.
How to Change Anxiety Medications
Choosing anxiety medications can feel overwhelming, especially when considering a transition from one to another.
If you’re currently taking Xanax and are curious about exploring buspirone as a potential alternative, careful consideration and open communication with your healthcare provider are crucial.
Here are some of our tips for making informed decisions about medication:
- Understand your medications: Knowing how anxiety medications work helps you identify which would be better suited to your specific condition.
- Know your needs and experiences: Are you primarily seeking quick relief or are you looking to manage symptoms on a daily basis? Have you experienced side effects with Xanax? Are you concerned about the possibility of dependence?
- Schedule a conversation with your doctor: Be open and honest about your experiences, concerns, and goals. They can provide valuable insights, helping you weigh the risks and benefits of each medication.
- Discuss your medical history: Knowing about other medications you're taking and lifestyle factors that might be contributing to your anxiety will help your doctor create a personalized treatment plan.
Switching medications is a process that requires careful planning and monitoring. Your doctor will likely recommend a gradual tapering off of Xanax to minimize withdrawal symptoms while slowly introducing buspirone.
It's essential to be patient during this transition, as it may take a few weeks to feel the full effects of buspirone. Ultimately, making an informed decision about your anxiety treatment empowers you to take control of your mental health journey.
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- “Clinical Bulletin: Benzodiazepines and Opioids.” BC Ministry of Mental Health and Addictions, 2021.
- Hu, X. “Benzodiazepine withdrawal seizures and management.” The Journal of the Oklahoma State Medical Association, 2011.
- Olfson et al. “Benzodiazepine Use in the United States.”JAMA Psychiatry, 2015.
- Elgarf et al. “Different Benzodiazepines Bind with Distinct Binding Modes to GABAA Receptors.” ACS Chemical Biology, 2018.
- Brett, J., and Murnion, B. “Management of benzodiazepine misuse and dependence.” Australian Prescriber, 2015.
- Soyka, M. “Treatment of Benzodiazepine Dependence.” The New England Journal of Medicine, 2017.

