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Updated on January 27, 2022

Pliva 434 Pill: Trazodone Hydrochloride

What is Pliva 434 (Trazodone Hydrochloride)?

Pliva 434 is a 100 mg dose of trazodone hydrochloride.

Trazodone hydrochloride is an FDA-approved, generic prescription drug given to adults to treat serious conditions, such as major depressive disorder (MDD).

Common pill imprints of the drug include:

Trazodone Hydrochloride 100 mg:

Pliva 434 Pill - Trazodone Hydrochloride

Trazodone Hydrochloride 50 mg:

Pliva 433 Pill - Trazodone Hydrochloride

Trazodone Hydrochloride 300 mg:

bar 733 Pill - Trazodone Hydrochloride

Trazodone Hydrochloride 150 mg:

Pliva 441 Pill - Trazodone Hydrochloride

However, some individuals may be more familiar with the drug’s other brand names like Oleptro®, Desyrel®, Desyrel Dividose®, and Trialodine® (even though the last two are no longer used). 

Pliva 434 is a type of serotonin receptor antagonist and reuptake inhibitor (SARI). This means that the drug helps increase the amount of serotonin in the brain to restore mental balance. Serotonin is a neurotransmitter produced in the brain that helps deliver nerve signals. It is also responsible for feelings of happiness, well-being, and good mood.

Health care professionals may prescribe this drug when other therapeutic options are not suitable. Pliva 434 is available as an oral tablet and as an extended-release tablet. Tablets should be stored in room temperature.

Individuals who have a personal or family medical history of the following should let their doctors know first before taking this drug:

  • Bipolar disorder
  • Heart disease (including heart attacks or irregular heartbeat)
  • Glaucoma (angle-closure type)
  • Blood pressure issues
  • Suicide attempts
  • Liver or kidney disease 
  • Bleeding disorder
  • Seizures or epilepsy

What Does Pliva 434 Do to You?

It is important to understand that this drug does not cure depression. Instead, Pliva 434 helps to manage symptoms of depression so that individuals may return to their usual selves. 

There are two formulations of Pliva 434: tablet and extended-release capsules. Tablets are taken with a meal or snack, while extended-release capsules are taken once daily.

In general, Pliva 434 may not take full effect until after two weeks have passed. Individuals should, therefore, continue following their doctor’s prescription order to ensure treatment efficacy.

Additionally, Pliva 434 can help treat other health conditions such as insomnia, schizophrenia (a mental disorder that causes abnormal thinking, lethargy, and intense or inappropriate emotions), and anxiety.

Health care professionals recommend taking the medication around bedtime due to the drug’s ability to cause drowsiness. 

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Side Effects of Trazodone (Pliva 434)

Pliva 434 can cause common side effects. Adverse effects include:

  • Headaches
  • Nausea/vomiting
  • Dry mouth
  • Diarrhea
  • Constipation
  • Tiredness or weakness
  • Unsteady gait 
  • Difficulty concentrating or remembering 
  • Confusion 
  • Pain in the muscles 
  • Sweating 
  • Stuffy nose
  • Allergic reaction
  • Changes in libido 

Seek medical attention if the use of Pliva 434 results in serious conditions including: 

  • Chest Pain
  • Arrhythmias
  • Coma 
  • Fainting 
  • Seizures 
  • Dyspnea (shortness of breath)
  • Unusual bruising or bleeding

It is important to speak to a healthcare professional about the full risks and benefits of Pliva 434, especially in younger individuals. The drug has been reported to increase suicidal thinking at the beginning of treatment or when dosing changes occur.  

Other health risks that have been associated with the use of trazodone hydrochloride include:

  • Priapism (long-lasting erections)
  • Mania (extended period of mood disturbance, in which an individual displays an excessive, abnormal amount of energy and hyperactivity) or hypomania (a milder form of mania)
  • Trouble sleeping
  • QT prolongation (an electrical disturbance in the heart that can trigger tachycardia)
  • Decreased heart beat and an arrhythmia

If new or worsening symptoms occur, it is important to call your doctor as soon as possible.

Trazodone Hydrochloride Warnings

Trazodone hydrochloride has a Food and Drug Administration boxed warning. This is the highest level of warning from the FDA. A boxed warning indicates potential dangerous drug effects. These effects may include:

Suicidal Thoughts and Behaviors

Antidepressant medications, including trazodone hydrochloride, can increase suicidal thoughts or behaviors. The risk is increased in pediatric, teen, and young adult patients. This is most common during the first few months of treatment, or after changing doses. Because of this, trazodone hydrochloride is not approved for pediatric patients.

Serotonin Syndrome

Trazodone hydrochloride can cause serotonin syndrome, which is the result of excessive amounts of serotonin in the body.

This is a life-threatening condition that can cause:

  • Agitation
  • Hallucinations
  • Confusion (difficulty thinking)
  • Nausea, vomiting, and diarrhea
  • Muscle twitching
  • Increased heart rate
  • High or low blood pressure
  • Fever
  • Coma

Serotonin syndrome is more likely to occur if you are also using other serotonergic drugs. These include antidepressants, MAOIs, triptans, fentanyl, tramadol, lithium, tryptophan, St. John's Wort, and buspirone.

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Trazodone Drug Interactions

It is important to speak with a medical care provider before taking trazodone hydrochloride with other medications. The combined use of drugs can cause unwanted drug interactions and serious side effects. 

Here are some drugs that can interact with trazodone hydrochloride:

Serotonergic medications

These types of drugs include triptans, tricyclic antidepressants, fentanyl, St. John’s Wort, tramadol, lithium, and monoamine oxidase inhibitors (MAOI or MAO inhibitors) such as linezolid, rasagiline, isocarboxazid, phenelzine, tranylcypromine, selegiline, and methylene blue.

Using these drugs while taking trazodone hydrochloride increases the risk of developing serotonin syndrome (when too much serotonin causes symptoms ranging from shivering and diarrhea to muscle rigidity, fever, and seizures). 

Aspirin, NSAIDs, antiplatelet and anticoagulant drugs (including warfarin)

When individuals take both trazodone hydrochloride and one of these drugs, the risk of bleeding increases. Combined use has also shown to interfere with serotonin reuptake (the process by which nerve cells reuse the chemical substance).

Macrolide antibiotics, including erythromycin

Seizure medication, including phenytoin

Medications used for seizures or epilepsy result in increased dizziness, drowsiness, confusion, and difficulty concentrating.

Digoxin

Trazodone intake may increase digoxin levels in the body which can lead to serious side effects and toxicity. These include vomiting, dizziness, vision problems, and irregular heart rate.

CNS depressants

These drugs may worsen the drowsiness effect caused by trazodone hydrochloride. Examples of such medications include sleeping pills, opioids, alcohol, and benzodiazepines. 

Diuretics

These drugs may increase the risk of developing hyponatremia (when sodium levels in your blood are abnormally low) when taking trazodone as well. 

Medicines for Migraines and Headaches

These drugs include sumatriptan, Imitrex, Maxalt, Treximet. They increase serotonin levels in the blood and can cause severe hypertension and increased heart rate which can be life threatening.

When individuals complete treatment with trazodone hydrochloride, it is important not to take MAOI within two weeks. Trazodone hydrochloride can still have some physiological effects on the body. 

When in doubt, it is best to seek medical advice to ensure a safe treatment. 

Is Pliva 434 Addictive?

In clinical studies with trazodone hydrochloride, investigators did not find drug-seeking behavior in individuals using the medication. Additionally, trazodone hydrochloride is not classified as a controlled substance by the United States Drug Enforcement Agency (DEA). 

This suggests that this type of medication has little to no potential for misuse and dependence. 

However, some cases have been reported of death from an overdose when the drug was ingested with other central nervous system (CNS) depressants. CNS depressants can include alcohol, diazepam, amobarbital, narcotic pain medications, opioids, and much more. 

If overdose is suspected, seek medical help immediately.  

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Trazodone Hydrochloride Statistics

23.8

Million

Estimated number of prescriptions of trazodone hydrochloride in the U.S.

14.24

Dollars

Average total drug cost for trazodone hydrochloride.

4.61

Dollars

Average out-of-pocket costs for trazodone hydrochloride.

What to Discuss With Your Healthcare Provider Before Taking Pliva 434

Are trazodone and Xanax the same thing?

No. Trazodone is an antidepressant, while Xanax is a benzodiazepine. Benzodiazepines are controlled substances under the U.S. Drug Enforcement Agency. This means that Xanax, unlike Trazodone, has a much higher potential of misuse and abuse. Also, Xanax helps to treat panic disorders, including panic attacks or anxiety. Xanax would not be a suitable option for depression.

Does trazodone work right away for sleep?

For those who are taking trazodone for insomnia, doctors will recommend taking the drug during bedtime. Because trazodone causes drowsiness, which may extend even a day after you took the pill, you must practice caution, especially in activities that require alertness.

Trazodone is not approved as a sleeping pill, but its side-effect of increased sleepiness is the reason why it may help you fall asleep.

How long do you sleep on trazodone?

Trazodone helps provide a better night’s rest by letting individuals sleep approximately 7 to 8 hours.

Does Trazodone affect memory?

Trazodone may affect memory. A side effect reported in people taking the drug is difficulty concentrating or remembering.

What happens if I miss a dose?

There is no problem when it comes to a missed dose. Individuals just need to take the dose as soon as they remember (assuming that it is not close in time to the next dose). 

Individuals should remember to avoid taking a double dose of the drug.

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Resources

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  1. “DailyMed - TRAZODONE HYDROCHLORIDE Tablet.” U.S. National Library of Medicine, National Institutes of Health, www.dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4006d439-e2de-4590-82e9-fc9d56e3ec1b.
  2. “Trazadone.” NHS Choices, NHS, 13 Dec. 2018, www.nhs.uk/medicines/trazodone/.
  3. “Trazodone: MedlinePlus Drug Information.” MedlinePlus, U.S. National Library of Medicine, 15 Apr. 2017, www.medlineplus.gov/druginfo/meds/a681038.html.
  4. Kane, Sean P. “Trazodone Hydrochloride.” Trazodone Hydrochloride - Drug Usage Statistics, ClinCalc DrugStats Database, 2018, clincalc.com/DrugStats/Drugs/TrazodoneHydrochloride.

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