Updated on October 28, 2024
5 min read

The Guide to Taking Pliva 434/433: Uses, Side Effects, and Warnings

Key Takeaways

Trazodone hydrochloride is a sedative in the class of medications called selective serotonin reuptake inhibitors (SSRIs). It’s an FDA-approved medication.

In this article, we’ll discuss whether you can get high from the medication. We’ll also go over the addiction and overdose risks, withdrawal symptoms, and side effects.

Can You Get High From Trazodone Hydrochloride?

While trazodone hydrochloride isn’t typically associated with producing a euphoric high like traditional recreational drugs, it can be misused in ways that lead to undesirable effects.

Trazodone’s primary purpose is to treat depression, anxiety, and sleep disorders. However, some people may seek to exploit its sedative properties for a sense of relaxation or altered mental state.

Here’s why you might not get a “high” from trazodone but the drug can still be classified as a substance of abuse:

  • Sedation: Trazodone primarily produces a calming effect, not a euphoric one. While this can be pleasant for some, it’s different from the intense pleasure or altered perception often associated with recreational drugs.
  • Cognitive impairment at high doses: At higher-than-prescribed doses, trazodone can cause cognitive impairment. This can be mistaken for a “high” by some, but it’s more akin to feeling mentally foggy or disoriented.
  • Risk of negative consequences: Misusing trazodone can lead to serious side effects, including addiction, withdrawal symptoms, and serotonin syndrome. These risks far outweigh any potential benefits of using it for non-medical purposes.
  • Dependence: The dependence people can have on trazodone is typically referred to as antidepressant discontinuation syndrome.

Trazodone is a prescription medication and should be used only as directed by a healthcare professional. If you have concerns about substance abuse or are struggling with mental health issues, we encourage seeking professional help.

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What is Pliva 434/433?

A 50 mg dose of trazodone hydrochloride is referred to as Pliva 433, and 100 mg is Pliva 434. These increase the production of serotonin in the brain to deliver nerve signals that are responsible for good moods.

However, it can’t cure depression, change your personality, or make you feel euphorically happy. It can only manage depression symptoms.

After you finish trazodone hydrochloride treatment it’s important to take a Monoamine oxidase inhibitor (MAOI) within two weeks. Trazodone hydrochloride can still have some physiological effects on the body, so seek medical advice to ensure a safe treatment.

Trazodone Hydrochloride 100 mg:

Pliva 434 Pill - Trazodone Hydrochloride

Trazodone Hydrochloride 50 mg:

Pliva 433 Pill - Trazodone Hydrochloride

Trazodone Hydrochloride 300 mg:

bar 733 Pill - Trazodone Hydrochloride

Trazodone Hydrochloride 150 mg:

Pliva 441 Pill - Trazodone Hydrochloride

Who is At Risk When Using Pliva 434/433?

Some people are at risk of experiencing side effects from Pliva 434/433 compared to others. People who have a personal or family medical history of the following should let their doctors know first before taking this drug:

  • Bipolar disorder
  • Heart disease (including heart attacks or irregular heartbeat)
  • Glaucoma (angle-closure type)
  • Blood pressure issues
  • Suicide attempts
  • Liver or kidney disease 
  • Bleeding disorder
  • Seizures or epilepsy

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Can You Get Withdrawal Symptoms from Trazodone?

Although there’s a very small chance of developing a dependence on trazodone hydrochloride, you can experience side effects if you suddenly stop using it.  These symptoms include:

  • Dizziness or lightheadedness
  • Nausea and vomiting
  • Shock-like sensations
  • Suicidal Thoughts
  • Vertigo or issues walking
  • Difficulties concentrating 
  • Headaches
  • Irritability
  • Chills
  • Depersonalization

Speak with your doctor about quitting or tapering off trazodone to prevent additional side effects. They can help you reduce your dosage gradually to prevent or reduce the likelihood of side effects.

Can You Overdose on Trazodone Hydrochloride?

Some cases of death from an overdose have been reported when the drug was ingested with other central nervous system (CNS) depressants. If you suspect an overdose, seek medical help immediately.

CNS depressants can include:

  • Alcohol
  • Diazepam
  • Amobarbital
  • Narcotic pain medications
  • Opioids 

What are the Side Effects of Trazodone Hydrochloride?

You may feel tired during the first few days of taking trazodone. Once the drug has taken effect, you will have less anxiety and better sleep.

However, this drug won’t take full effect until two weeks have passed. You should continue to follow the doctor’s prescription to ensure treatment efficacy.

Additionally, the drug has been reported to increase suicidal thinking at the beginning of treatment or when dosing changes occur. Other side effects include:

  • Headaches
  • Nausea and vomiting
  • Dry mouth
  • Diarrhea or constipation
  • Tiredness or weakness
  • Unsteady gait 
  • Difficulty concentrating or remembering 
  • Confusion 
  • Pain in the muscles 
  • Sweating 
  • Stuffy nose
  • Changes in libido

Other Potential Risks of Trazodone Hydrochloride

Trazodone hydrochloride has an FDA label warning people about the potential dangers of this medication. These potential risks include suicidal thoughts or behaviors and serotonin syndrome.

Other health risks that have been associated with the use of trazodone hydrochloride include:

  • Priapism (long-lasting erections)
  • Mania or hypomania
  • QT prolongation
  • Insomnia
  • Arrhythmia

Contact a doctor if you experience any of these symptoms. You should especially call them if you’re experiencing serotonin syndrome because the condition can be fatal.

We strongly advise seeking medical attention if trazodone causes serious conditions, such as:

  • Chest pain and arrhythmias
  • Fainting 
  • Seizures 
  • Dyspnea (shortness of breath)
  • Unusual bruising or bleeding
  • Coma

Trazodone Drug Interactions

Pliva 434 and 433 can interact with other medications. Be sure to talk to your doctor about any prescription drugs you’re taking before using trazodone hydrochloride.

Combining the drug with other substances can cause unwanted and serious side effects. Here are some drugs that can interact with trazodone hydrochloride:

  • Serotonergic medications (triptans, tricyclic, & other antidepressants)
  • Aspirin, NSAIDs, antiplatelet, & anticoagulant drugs
  • Macrolide antibiotics
  • Seizure medication
  • Digoxin
  • CNS depressants (sleeping pills, alcohol, opioids, & benzodiazepines)
  • Diuretics
  • Medicines for migraines and headaches (Sumatriptan, Imitrex, & Maxalt)

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Treatment for Trazodone Abuse

Trazodone abuse requires an exhaustive assessment of your health and history of substance abuse. This will be important when developing an addiction treatment plan for you.

People respond to treatment differently, so talking to your doctor about your needs is important. An addiction treatment program for Trazodone abuse may include the following:

  • Medical detox: Medically supervised detox used to avoid harmful withdrawal effects.
  • Inpatient treatment: Involves checking yourself into a rehab facility for 24-hour medical supervision.
  • Outpatient treatment: A treatment program where patients are freely allowed to leave the rehab facility.
  • Cognitive behavioral therapy (CBT): A short-term therapy technique that explores the link between thought patterns and addiction.
  • Dual-diagnosis treatment: A treatment program that addresses substance use disorders alongside co-occurring disorders.
  • 12-step programs: A support group designed to help guide you through the recovery process and maintain sobriety.drug include:1

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Updated on October 28, 2024

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