Trazodone hydrochloride (pronounced as TRAZ-oh-done) is an FDA-approved, generic prescription drug given to adults to treat serious conditions, such as major depressive disorder (MDD). Common pill imprints of the drug include:
However, some individuals may be more familiar with the drug’s other brand names like Oleptro®, Desyrel®, Desyrel Dividose®, and Trialodine® (even though the last two are no longer used).
Pliva 434 is a type of serotonin receptor antagonist and reuptake inhibitor (SARI). This means that the drug helps increase the amount of serotonin in the brain to restore mental balance. Serotonin is a natural chemical produced by the brain for it and nerve cells to function.
Health care professionals may prescribe this drug when other therapeutic options are not suitable. Pliva 434 is available as an oral tablet and as an extended-release tablet. Tablets should be stored in room temperature.
Individuals who have a personal or family medical history of the following should let their doctors know first before taking this drug:
It is important to understand that this drug does not cure depression. Instead, Pliva 434 helps to manage depression so that individuals may return to their usual selves.
In general, Pliva 434 may not take full effect until after two weeks have passed. Individuals should, therefore, continue following their doctor’s prescription order to ensure treatment efficacy.
Additionally, Pliva434 can help treat other health conditions such as insomnia, schizophrenia (a mental disorder that causes abnormal thinking, lethargy, and intense or inappropriate emotions), and anxiety. Health care professionals recommend taking the medication around bedtime due to the drug’s ability to cause drowsiness.
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Pliva 434 can cause common side effects. Adverse effects include:
Seek medical attention if the use of Pliva 434 results in serious condition including:
It is important to speak to a healthcare professional about the full risks and benefits of Pliva 434, especially in younger individuals. The drug has been reported to increase suicidal thinking at the beginning of treatment or when dosing changes occur.
Other health risks that have been associated with the use of Pliva 434 include:
If new or worsening symptoms occur, it is important to let the physician know as soon as possible.
In clinical studies with trazodone hydrochloride, investigators did not find drug-seeking behavior in individuals using the medication. Additionally, trazodone hydrochloride is not classified as a controlled substance by the United States Drug Enforcement Agency (DEA).
This suggests that this type of medication has little to no potential for abuse and dependence.
However, some cases have been reported of death from an overdose when the drug was ingested with other central nervous system (CNS) depressants. CNS depressants can include alcohol, diazepam, amobarbital, narcotic pain medications, opioids, and much more.
If overdose is suspected, it is important to seek medical help immediately.
It is important to speak with a medical care provider before taking trazodone hydrochloride with other medications. The combined use of drugs can cause unwanted drug interactions and serious side effects.
Here are some drugs that can interact with trazodone hydrochloride:
When individuals complete treatment with trazodone hydrochloride, it is important not to take MAOI within two weeks. Trazodone hydrochloride can still have some physiological effects on the body.
When in doubt, it is best to seek medical advice to ensure a safe treatment.
Estimated number of prescriptions of trazodone hydrochloride in the U.S.
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No. Trazodone is an antidepressant, while Xanax is a benzodiazepine. Benzodiazepines are controlled substances under the U.S. Drug Enforcement Agency. This means that Xanax, unlike Trazodone, has a much higher potential of misuse and abuse. Also, Xanax helps to treat panic disorders, including panic attacks or anxiety. Xanax would not be a suitable option for depression.
For those who are taking trazodone for insomnia, doctors will recommend taking the drug during bedtime. The drug’s ability to induce drowsiness makes it important to remember that cognitive impairment may occur even during the following day of taking the medication.
Trazodone helps provide a better night’s rest by letting individuals sleep approximately 7 to 8 hours.
Trazodone may affect memory. A side effect reported in people taking the drug is difficulty concentrating or remembering.
There is no problem when it comes to a missed dose. Individuals just need to take the dose as soon as they remember (assuming that it is not close in time to the next dose).
Individuals should remember to avoid taking a double dose of the drug.
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“DailyMed - TRAZODONE HYDROCHLORIDE Tablet.” U.S. National Library of Medicine, National Institutes of Health, www.dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4006d439-e2de-4590-82e9-fc9d56e3ec1b.
“Trazadone.” NHS Choices, NHS, 13 Dec. 2018, www.nhs.uk/medicines/trazodone/.
“Trazodone: MedlinePlus Drug Information.” MedlinePlus, U.S. National Library of Medicine, 15 Apr. 2017, www.medlineplus.gov/druginfo/meds/a681038.html.
Kane, Sean P. “Trazodone Hydrochloride.” Trazodone Hydrochloride - Drug Usage Statistics, ClinCalc DrugStats Database, 2018, clincalc.com/DrugStats/Drugs/TrazodoneHydrochloride.