What is Pliva 434 (Trazodone Hydrochloride)?

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Trazodone hydrochloride (pronounced as TRAZ-oh-done) is an FDA-approved, generic prescription drug given to adults to treat serious conditions, such as major depressive disorder (MDD). Common pill imprints of the drug include:

  • Pliva 434 (100 mg)
  • Pliva 433 (50 mg)
  • Pliva 441 (150 mg — these pills are trapezoid-shaped)

However, some individuals may be more familiar with the drug’s other brand names like Oleptro®, Desyrel®, Desyrel Dividose®, and Trialodine® (even though the last two are no longer used). 

Pliva 434 is a type of serotonin receptor antagonist and reuptake inhibitor (SARI). This means that the drug helps increase the amount of serotonin in the brain to restore mental balance. Serotonin is a natural chemical produced by the brain for it and nerve cells to function.

pliva 434

Health care professionals may prescribe this drug when other therapeutic options are not suitable. Pliva 434 is available as an oral tablet and as an extended-release tablet. Tablets should be stored in room temperature.

Individuals who have a personal or family medical history of the following should let their doctors know first before taking this drug:

  • Bipolar disorder
  • Heart disease (including heart attacks or irregular heartbeat)
  • Glaucoma (angle-closure type)
  • Blood pressure issues
  • Suicide attempts
  • Liver or kidney disease 

What Does Pliva 434 Do to You?

It is important to understand that this drug does not cure depression. Instead, Pliva 434 helps to manage depression so that individuals may return to their usual selves. 

In general, Pliva 434 may not take full effect until after two weeks have passed. Individuals should, therefore, continue following their doctor’s prescription order to ensure treatment efficacy.

Additionally, Pliva434 can help treat other health conditions such as insomnia, schizophrenia (a mental disorder that causes abnormal thinking, lethargy, and intense or inappropriate emotions), and anxiety. Health care professionals recommend taking the medication around bedtime due to the drug’s ability to cause drowsiness. 

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Side Effects of Trazodone (Pliva 434)

Pliva 434 can cause common side effects. Adverse effects include:

  • Headaches
  • Nausea/vomiting
  • Dry mouth
  • Diarrhea
  • Constipation
  • Tiredness or weakness
  • Unsteady gait 
  • Difficulty concentrating or remembering 
  • Confusion 
  • Pain in the muscles 
  • Sweating 
  • Stuffy nose
  • Allergic reaction
  • Changes in libido 

Seek medical attention if the use of Pliva 434 results in serious condition including: 

  • Chest Pain
  • Arrhythmias
  • Coma 
  • Fainting 
  • Seizures 
  • Dyspnea (shortness of breath)
  • Unusual bruising or bleeding

It is important to speak to a healthcare professional about the full risks and benefits of Pliva 434, especially in younger individuals. The drug has been reported to increase suicidal thinking at the beginning of treatment or when dosing changes occur.  

Other health risks that have been associated with the use of Pliva 434 include:

  • Priapism (long-lasting erections)
  • Mania (extended period of mood disturbance, in which an individual displays an excessive, abnormal amount of energy and hyperactivity) or hypomania (a milder form of mania)
  • Trouble sleeping
  • QT prolongation (an electrical disturbance in the heart that can trigger tachycardia)

If new or worsening symptoms occur, it is important to let the physician know as soon as possible.

Is Pliva 434 Addictive?

In clinical studies with trazodone hydrochloride, investigators did not find drug-seeking behavior in individuals using the medication. Additionally, trazodone hydrochloride is not classified as a controlled substance by the United States Drug Enforcement Agency (DEA). 

This suggests that this type of medication has little to no potential for abuse and dependence. 

However, some cases have been reported of death from an overdose when the drug was ingested with other central nervous system (CNS) depressants. CNS depressants can include alcohol, diazepam, amobarbital, narcotic pain medications, opioids, and much more. 

If overdose is suspected, it is important to seek medical help immediately.  

What Other Drugs Affect Trazodone?

It is important to speak with a medical care provider before taking trazodone hydrochloride with other medications. The combined use of drugs can cause unwanted drug interactions and serious side effects. 

Here are some drugs that can interact with trazodone hydrochloride:

  • Serotonergic medications — these types of drugs include triptans, tricyclic antidepressants, fentanyl, St. John’s Wort, tramadol, lithium, and monoamine oxidase inhibitors (MAOI or MAO inhibitors) such as linezolid, rasagiline, isocarboxazid, phenelzine, tranylcypromine, selegiline, and methylene blue. Using these drugs while taking trazodone hydrochloride increases the risk of developing serotonin syndrome (when too much serotonin causes symptoms ranging from shivering and diarrhea to muscle rigidity, fever, and seizures). 
  • Aspirin, NSAIDs, antiplatelet and anticoagulant drugs (including warfarin) — when individuals take both trazodone hydrochloride and one of these drugs, the risk of bleeding increases. Combined use has also shown to interfere with serotonin reuptake (the process by which nerve cells reuse the chemical substance).
  • Macrolide antibiotics, including erythromycin
  • Seizure medication, including phenytoin
  • Over-the-counter medicines
  • CNS depressants — these drugs may worsen the drowsiness effect caused by trazodone hydrochloride. Examples of such medications include sleeping pills, opioids, alcohol, benzodiazepines. 
  • Diuretics — these drugs may increase the risk of developing hyponatremia (when sodium levels in your blood are abnormally low) when taking trazodone as well. 

When individuals complete treatment with trazodone hydrochloride, it is important not to take MAOI within two weeks. Trazodone hydrochloride can still have some physiological effects on the body. 

When in doubt, it is best to seek medical advice to ensure a safe treatment. 

Trazodone Hydrochloride Statistics



Estimated number of prescriptions of trazodone hydrochloride in the U.S.



Average total drug cost for trazodone hydrochloride.



Average out-of-pocket costs for trazodone hydrochloride.

What to Discuss With Your Healthcare Provider Before Taking Pliva 434

Is trazodone and Xanax the same thing?

No. Trazodone is an antidepressant, while Xanax is a benzodiazepine. Benzodiazepines are controlled substances under the U.S. Drug Enforcement Agency. This means that Xanax, unlike Trazodone, has a much higher potential of misuse and abuse. Also, Xanax helps to treat panic disorders, including panic attacks or anxiety. Xanax would not be a suitable option for depression.

Does trazodone work right away for sleep?

For those who are taking trazodone for insomnia, doctors will recommend taking the drug during bedtime. The drug’s ability to induce drowsiness makes it important to remember that cognitive impairment may occur even during the following day of taking the medication.

How long do you sleep on trazodone?

Trazodone helps provide a better night’s rest by letting individuals sleep approximately 7 to 8 hours.

Does Trazodone affect memory?

Trazodone may affect memory. A side effect reported in people taking the drug is difficulty concentrating or remembering.

What happens if I miss a dose?

There is no problem when it comes to a missed dose. Individuals just need to take the dose as soon as they remember (assuming that it is not close in time to the next dose). 

Individuals should remember to avoid taking a double dose of the drug.

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Resources +

“DailyMed - TRAZODONE HYDROCHLORIDE Tablet.” U.S. National Library of Medicine, National Institutes of Health, www.dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4006d439-e2de-4590-82e9-fc9d56e3ec1b.

“Trazadone.” NHS Choices, NHS, 13 Dec. 2018, www.nhs.uk/medicines/trazodone/.

“Trazodone: MedlinePlus Drug Information.” MedlinePlus, U.S. National Library of Medicine, 15 Apr. 2017, www.medlineplus.gov/druginfo/meds/a681038.html.

Kane, Sean P. “Trazodone Hydrochloride.” Trazodone Hydrochloride - Drug Usage Statistics, ClinCalc DrugStats Database, 2018, clincalc.com/DrugStats/Drugs/TrazodoneHydrochloride.

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